Holoprosencephaly

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Figer-1

📄 Report Sample Line- Alobar holoprosencephaly (During First Trimester / NT Screening)
Gray scale imaging of a fetal brain showing a monoventricular brain cavity with absence of midline falx, fused thalami, and distorted craniofacial structures, suggestive of alobar holoprosencephaly.


Conclussion: 📋 Sonographic features are highly suggestive of holoprosencephaly, most consistent with the alobar form, a severe and lethal forebrain malformation.
Recommendation: Recommend urgent referral to fetal medicine specialist for detailed neurosonography and genetic counseling. Karyotyping or chromosomal microarray testing is advised to assess for associated anomalies such as trisomy 13.
Note: Associated facial anomalies (e.g., hypotelorism, proboscis) may also be present.

Figer-2

📄 Report Sample Line- Semilobar holoprosencephaly (During First Trimester / NT Screening)
Gray scale imaging ofa fetal brain showing a partial separation of the cerebral hemispheres posteriorly, with a single ventricular cavity anteriorly, partially formed falx cerebri, and incomplete division of the thalami, consistent with semilobar holoprosencephaly.


Conclussion: 📋 Sonographic features are highly suggestive of holoprosencephaly, most consistent with the semilobar a moderate form of forebrain malformation with significant neurodevelopmental implications.
Recommendation: Recommend urgent referral to fetal medicine specialist for detailed neurosonography and genetic counseling. Karyotyping or chromosomal microarray testing is advised to assess for associated anomalies such as trisomy 13.
Note: Subtle midline facial anomalies such as hypotelorism may also be noted.

Figer-3

📄 Report Sample Line- Lobar Holoprosencephaly
Gray scale imaging of a fetal brain showing near-complete separation of cerebral hemispheres, with subtle fusion of the frontal lobes, presence of an interhemispheric fissure and falx cerebri, and a mildly abnormal configuration of the frontal horns, suggestive of lobar holoprosencephaly


Conclussion: 📋 Imaging findings are consistent with lobar holoprosencephaly, the mildest form of forebrain malformation, which may still be associated with neurodevelopmental delay and chromosomal anomalies.
Recommendation: Recommend referral to a fetal medicine specialist for detailed neurosonography and genetic counseling. Fetal MRI and genetic testing (including karyotyping or chromosomal microarray) are advised to evaluate associated anomalies and assist in prognostic assessment. Note: Facial anomalies may be minimal or absent.